breaktore.blogg.se

Outlier analysis also identified putative PAX5amp cases and revealed partial tandem duplication (PTD) spanning IKZF1 N159Y in the B-ALL with mutated N159Y subtype.

Outlier analysis of known and novel IKZF1, ERG, and PAX5 isoforms was 97.0% (32/33), 90% (9/10), and 100% (6/6) sensitive and 97.8% (226/231), 100% (35/35), and 88.5% (23/26) specific for IKZF1 intragenic or 3’ deletions, DUX4r, and PAX5 intragenic deletions respectively, where false positives were favored to represent low-level deletions below the limit of DNA-based detection. In this study, we screened for outlier expression of isoforms within targeted RNA sequencing assays designed for fusions. The high-risk IKZF1 plus signature depends on gene deletions including PAX5 while intragenic PAX5 amplifications (PAX5amp) are recurrent in the provisional B-ALL with PAX5-alteration subtype. Aberrant ERG isoforms have been proposed as markers of the favorable-risk DUX4-rearranged ( DUX4r) subtype while deletion-mediated IKZF1 isoforms are associated with adverse prognosis in non- DUX4r B-ALL. The Samsung CEO added that the group will help improve competitive capacity for 50 Vietnamese suppliers, and promote cooperation with Vietnamese universities and research establishments./.Recognition of aberrant gene isoforms indicative of underlying DNA events can impact molecular classification and risk stratification of B lymphoblastic leukemia (B-ALL). The group also plans to launch a R&D centre in Hanoi in late 2022 or early 2023, which will serve not only Vietnam but also the entire Southeast Asian region.

He informed PM Pham Minh Chinh that Samsung Vietnam earned 34.3 billion USD from exports in the first six months of 2022, up 18% from the same period last year, adding that the company aims for 69 billion USD in export turnover this year and plans to invest an additional 3.3 billion USD in Vietnam.Īccording to Roh, Samsung Electronics is preparing for the trial production of Flip-chip Ball Grid Array in Vietnam and commercial production is slated to begin in July next year at its factory in Thai Nguyen province, northern Vietnam. He thanked the Government and agencies of Vietnam for their support which he said helped Samsung overcome pandemic-caused difficulties and created a favourable environment for the group’s operations amidst a changing world.

The Samsung executive appreciated Vietnam’s efforts and measures to put the pandemic under control and restore socio-economic development. He also called on Samsung to continue giving feedback on Vietnam’s policies, institutions and mechanisms, and act as a bridge to bring more investors from the RoK and over the world to Vietnam, thus diversifying supply chains. “The Vietnamese government is committed to creating the best possible conditions for foreign investors in general and Samsung in particular,” Chinh said, pledging to seriously consider and actively handle Samsung’s proposals, including the training of human resources to meet the requirements of enterprises and investors.

The RoK is the largest foreign investor in Vietnam with 9,383 valid investment projects worth nearly 80 billion USD, he said, describing Samsung’s investment in Vietnam as a bright example. He noted that the RoK is now the third largest trade partner of Vietnam, with bilateral trade value reaching 78 billion USD in 2021, accounting for 11.6% of Vietnam’s total foreign trade. The Government leader highlighted the outstanding development of the strategic cooperative partnership between Vietnam and the RoK in all fields. PM Pham Minh Chinh (R) and Samsung Electronics CEO Roh Tae-Moon at the reception in Hanoi (Photo: VNA) He suggested that Samsung continue to play a leading role in supporting personnel training and capacity building for Vietnamese enterprises so that more of them will be able to join Samsung’s supply chain and development ecosystem.